CAREER OPPORTUNITIES
Community Career Opportunities
CENE is pleased to share the following career opportunities with our community. For more information, please contact the company directly. If you or your company would like to post a career opportunity, please fill out the form here or contact connect@thecene.org.
Abdera Therapeutics
Vancouver, British Columbia
Career Opportunities
Abdera Therapeutics Inc. is a precision oncology company developing next-generation targeted radiation therapies - one of the most cutting-edge and highly promising areas of drug development. The company is built on a proprietary modular technology platform optimized for the delivery of radioisotopes to selectively destroy tumor cells while sparing healthy cells. Abdera is using this platform to enable the rapid development of a broad range of safe and efficacious therapies serving cancer patients with limited treatment options.
Abdera Therapeutics is growing rapidly and seeking key new team members who thrive at the cutting-edge of innovation. Come join us and be a part of the ground-breaking team set to unlock the power of targeted radiotherapy!
At Abdera Therapeutics, we are looking for curious and committed individuals who are ready for the opportunity to transform the way people living with cancer can be treated. We are relentless in our focus to offer new hope to families facing devastating diagnoses. We are in search of team members who work collaboratively with a diverse group of colleagues, respectfully engaging one another while collectively and inclusively tackling any challenges we may face. We are building an exciting and fast paced company passionate about discovering and developing tomorrow’s most innovative cancer therapies.
Job Opening: Senior Director, Radiochemistry and Radiopharmaceutical Development
Location: In Person
Principal Responsibilities:
Leads the process development of therapeutic and imaging radiopharmaceuticals and transfer of these processes to CDMOs to support cGMP radiopharmaceutical manufacturing for IND enabling studies and for use in clinical trials.
Leads the development and validation of analytical procedures used for the in process testing and release of the radiopharmaceutical for use in preclinical and clinical studies (e.g., ITLC, SEC, HPLC, IRF determination).
Trouble shoots radiopharmaceutical process development and analysis.
Writes and executes protocols for analytical equipment and validation of analytical methodologies as per ICH guidelines.
Leads formulation optimization to ensure drug product stability.
Working with the CMC and regulatory teams, prepares the radiochemistry CMC section of regulatory filings (IND, NDA and equivalent)
Leads technical relationships with radiopharmaceutical CDMOs and radioisotope suppliers.
Qualifications, Education & Experience:
PhD in radiochemistry, chemistry, chemical engineering, or other relevant discipline
5+ years’ experience establishing and running process and analytical development and/or GMP laboratories in the radiochemistry, radiopharmaceutical manufacturing, organic chemistry, or process chemistry field.
Hands on experience with radiochemistry. Experience with Lu-177, Ac-225, In-111 & Cu-64 radiopharmaceuticals a strong asset.
Experience in quality control testing of radiopharmaceuticals.
Strong working knowledge of radiation safety requirements within a laboratory setting.
Working knowledge of GMP manufacturing and applicable FDA, EMA, Health Canada, ICH regulations.
Skills & Abilities:
Experience in the development of Ac-225, Lu-177, In-111 and Cu-64 based radiopharmaceuticals in the academic and/or industry setting.
Experience with quality control for identity and quantitation using various instruments such as HPLC, ITLC, Liquid Chromatography/mass spectrometry (LCMS), gamma spectrometry and liquid scintillation.
Knowledgeable in writing of relevant CMC sections, development reports for IND, NDA, and IMPD, to regulatory agencies including FDA and EMEA.
Good command of radiation safety regulations and guidelines is preferred
Understands chemistry manufacturing and controls (CMC) documentation for novel compounds consistent with requirements for IND, NDA, and other regulatory pathways.
Technical experience with radiolabeling of antibodies and other targeting molecules with metal radioisotopes.
Visit this page to apply for the position.
Job Opening: Director, Preclinical Pharmacology
Location: In Person
Principal Responsibilities:
Oversees the design, planning, execution and, analysis of the companies' preclinical pharmacology and toxicology studies in collaboration with project team members
Manages preclinical studies with external contract research organizations (CROs) and coordinates supporting internal activities
Write and review study protocols and reports
Identifies and develops appropriate in vivo pharmacology models for discovery research and development of drug candidates in oncology indications
Provides direct support for the companies' preclinical development programs including planning and oversight of IND enabling studies
Assists in regulatory filings including but not limited to authoring of reports, pre-IND, and IND
Provides leadership and oversight of In-vivo Biology participation in cross-functional teams
Qualifications, Education & Experience:
PhD with a minimum of 5 years’ industrial experience in in-vivo pharmacology or toxicology
Direct experience with antibody or protein-based drug development is essential
Experience in managing out-sourced studies at CRO’s is requirement
Expertise in oncology and related therapeutic development preferred
Skills and Abilities:
Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team.
Ability to establish and maintain effective working relationships
Strong leadership skills with the proven ability to manage concurrent deliverables work effectively in a challenging milestone-driven environment
Good written and verbal communication skills with ability to present to stakeholders
Visit this page to apply for the position.
Abdera is an equal opportunity employer that is committed to diversity and inclusion in the workplace. At Abdera, we prohibit harassment of any kind and any form of discrimination including but not limited to discrimination based on race, color, sex, religion, marital status, sexual orientation, national origin, disability, veteran status, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.
This is applicable to all employment practices within our organization, including hiring, recruiting, promotion, termination, layoff, recall, leave of absence, compensation, benefits, training, and apprenticeship.
